Mar1bei department of public health, pharmacology and toxicology and department of clinical studies, faculty of veterinary medicine, p. Original article antioxidant and hepatoprotective effect of. Infliximab modulates cisplatininduced hepatotoxicity in rats. Drug induced hepatotoxicity is the most common reason cited for withdrawal of already approved drugs from the market and accounts for more than 50 percent of cases of acute liver failure in the united states. Pdf effect of ethanol extract of pyrenacantha staudtii. Induced liver injury in spraguedawley rats sciencecentral. Histopatholoical ealuation of iethyl phthalate inuce hepatotoxicity on rat 4 opyriht. Amelioration of paracetamolinduced hepatotoxicity in rat by the. The present study is aimed at determining the hepatoprotective activity of methanol extract of m. Numerous plant resin content essential oils with terpenes and sesquiterpenes have shown hepatoprotective activity. Rats were divided into five groups and received 10% dmso negative control, 50 mgkg nacetylcysteine nac. Quinuronium induced hepatotoxicity in rats sciencedirect.
For this purpose, male wistar rats were randomly distributed into 6 groups of 8 rats each. Ticlopidineinduced hepatotoxicity in a gshdepleted rat. The effect of ethanol extract of pyrenacantha staudtii leaves on carbontetrachloride ccl4 induced hepatotoxicity in rats was studied. Group 1 normal control group and group 2 toxin control group received 0. Hepatoprotective activity of ethanol extract of conyza b. Our aim was to investigate the potential of paracetamol to a ect certain mitochondrial parameters in rats.
Paracetamol induced hepatotoxicity in adult sprague dawley rats. The ameliorative potential of probiotics andor silymarin on. Animals of groups 3, 4 and 5 were treated with oc 100, 250 and 500 mgkg, po for 4 days and. Evaluation of hepatoprotective and antioxidant activity of. Effect of oleogumresin on ethanol induced hepatotoxicity in rats. Pyrazinamideinduced hepatotoxicity and gender differences in. Subacute toxicopathological studies of methotrexate in. Liver damage was induced in rats by administering ethanol 5 gkg, 20% wv p. Pdf affect of silymarin on serum levels of alt and ggt. Histopathological evaluation of diethyl phthalate induced. The hepatoprotective activity of conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice. Jambilingappa, evaluation of hepatoprotective activity of aqueous extract of azadirachta indica neem leaves against paracetamol induced hepatotoxicity in albino rats, pharmacologyonline, vol. Organism names see more details, the herbal formulation showed dose dependent effect at the doses of 300 and 600 mgkg body weight and compared to 100 mgkg dose of silymarin in preventing the rise in the levels of alp, sgot, sgpt and bit. Effect of oleogumresin on ethanolinduced hepatotoxicity in.
The rats of group i received only deionised water as control while, group ii, iii and iv were given lead. E ect of quercetin on paracetamolinduced rat liver. Nnitrosodiethylamine ndea induced hepatotoxicity in swiss albino rats fahad ali, rahul, falaq naz, smita jyoti, yasir hasan siddiquen section of genetics, department of zoology, faculty of life sciences, aligarh muslim university, aligarh, uttar pradesh 202002, india received february 2014. Subacute toxicopathological studies of methotrexate in wistar. Pyrazinamide pza is a wellknown first line antituberculosis drug used in combination with other drugs such as isoniazid and rifampicin. In overdoses, it is a potent hepatotoxin, producing fulminant hepatic and renal tubular necrosis, which can be lethal in human and. Senthilkumar abstract to investigate the protective effect of the leaf extract of andrographis paniculata ap against ethanol induced liver toxicity in male albino rats. Influence of age on aluminuminduced hepatotoxicity in the. Song z, zhou z, chen t, hill d, kang j, barve s, mcclain c. Hepatoprotective potential of ethanolic extract of pandanus. Although sole administration of either tic or bso showed no signs of hepatotoxicity, combined administration of tic with bso induced hepatotoxicity, which was characterized by centrilobular necrosis of the.
Rats fed ethanol from 21 to days were subjected to one or more episodes of hypoxia 6% o2 in order to determine if ethanol predisposed to centrilobular liver necrosis induced by hypoxia. The herb in full bloom was collected, washed, aerial parts separated, air dried, powdered, and soaked in methanol for 72 h. Antioxidant effect of hemidesmus indicus on ethanol induced hepatotoxicity in rats. Apap hepatotoxicity is caused by its reactive metabolite nacetylpbenzoquinone imine napqi, which causes oxidative stress and glutathione gsh depletion, a prerequisite for apap induced hepatotoxicity 6, 7. Antioxidant modulation of nevirapine induced hepatotoxicity. Phorate induced hepatotoxicity in rats iosr journals. Swertiamarin attenuates carbon tetrachloride ccl4induced liver. Rats were divided into 6 groups with 8 animals per group and received doses of the antioxidants jobelyn 10. It has not been established if an outbred rat strain wistars and an inbred rat strain lewis rats exhibit the same. Hepatoprotective activity of leptadenia reticulata stems. Infliximab modulates cisplatin induced hepatotoxicity in rats medine cumhur cure, 1 erkan cure, 2 y. Aug 01, 2014 read carbon tetrachloride induced hepatotoxicity in rat is reversed by treatment with riboflavin, international immunopharmacology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Hepatotoxicity of acetaminophen after chronic ethanol feeding for 46 wk, serum got activity was increased significantly compared with pairfed controls 81. Hepatotoxic rats pretreated with nac or memc exhibited significant decrease in alt and ast enzymes level. Amelioration of paracetamolinduced hepatotoxicity in rat. Amelioration of paracetamolinduced hepatotoxicity in rat by. B 250 mgkg and 500 mgkg produced p in paracetamol induced liver marker enzymes and total bilirubin, but its 750 mgkg showed remarkable decline in alt, ast, alp and tb levels, compared to the reference. The biochemical observations play as supplementary component with histopathological assessment of rat liver sections. Hepatoprotective effect of silymarin silybum marianum on.
Affect of silymarin on serum levels of alt and ggt in ethanol induced hepatotoxicity in albino rats october 2009 journal of ayub medical college, abbottabad. Group i served as untreated control and fed orally with normal saline 5mlkg body weight daily for seven days. Inhalation exposure also made it possible to study the effect of starvation on liver damage in phenobarbitonepretreated rats exposed to cs2. Unfortunately, pza suffered from a high rate of hepatotoxicity and hyperuricemia, which has not been clearly elucidated, hindering its wide application for therapeutic p toxicology research 2017 most downloaded articles. Phorate induced hepatotoxicity in rats sangeetha g s, muraleedhara kurup, helen a dept. Organophosphorus compounds induce oxidative stress leading to generation of free radicals and alterations in antioxidant and scavengers of oxygen free radicals. To that end we studied the e ect of paracetamol on mitochondrial respiration, atpase, glutathion peroxidase and glutathion reductase activities.
Paracetamol induced hepatotoxicity in rats acute model animals were randomized and divided into seven groups ivii of six animals in each group. Carbohydratefat relationships in rats article pdf available in toxicological sciences 471. Increased hepatotoxicity of acetaminophen after chronic. Lee at the division of digestive and liver diseases, university of texas southwestern medical center, 5323 harry hines blvd. Fifty wistar rats were used, these being divided in four groups, one being the control receiving only water and the other groups receiving graded doses of equisentum arvense l. Pdf twelve male albino rats of 68 weeks old, weighing 150200 gm each were divided into two groups of 6 rats each. Ethanol also potentiated the hepatotoxicity of tce, but not 1, 1, 1trichloroethane, in rats exposed to high solvent concentrations 18 h after ingestion of ethanol at 5 gkg cornish and adefuin, 1966. Effects of nacetylcysteine on ethanol induced hepatotoxicity in rats fed via total enteral nutrition author links open overlay panel martin j. Abstract the present study was carried out to determine the severe hepatotoxicity and nephrotoxicity of gasoline on liver, kidney, hematological and oxidative stress parameters in wistar male albino rats.
The protective effects of aqueous extracts of the fruit rind of garcinia indica gie on ethanol induced hepatotoxicity and the probable mechanisms involved in this protection were investigated in rats. The effects of toluene in dimethylformamide dmfinduced hepatotoxicity were investigated with respect to the induction of cytochrome p450 cyp and the. In prophylactic in vivo studies with the ethanol induced hepatotoxicity in rats rats subject category. To evaluate the hepatoprotective potential of ethyl acetate fraction of ziziphus oenoplia l. It is concluded that ethyl acetate fraction has an effective hepatoprotective action against paracetamol induced hepatic injure in rats. Sixteen male wistar rats of 100170g body weight divided. Rats in 4 treatment groups with 6 male and 6 female rats each were administered methotrexate group ii to iv at the dose rate of 0. Ra was given one hour prior to etoh by oral gavage for 28 days. These changes were exaggerated among the senile rats which proved that senile rats are more susceptible to the hepatoxicity induced by aluminum. Sep 25, 2010 we investigated hepatotoxicity induced by ticlopidine tic in glutathione gsh depleted rats by pretreatment of a wellknown gsh synthesis inhibitor, lbuthionines,rsulfoxinine bso. The rats were divided into eight groups of which two served as control group i. Hepatoprotective activity of leptadenia reticulata stems against carbon tetrachloride induced hepatotoxicity in rats amit kumar nema 1, abhinav agarwal 2, varsha kashaw 1 1 pharmacognosy research laboratory, sagar institute of pharmaceutical sciences, sagar, madhya pradesh, india 2 pharmaceutics research laboratory, department of pharmaceutical sciences, dr.
Since previous studies showed that nvp hepatotoxicity may be due to oxidative stress via generation of oxidative radicals, this study sought to evaluate the protective effects of antioxidants in alleviating nvp induced hepatotoxicity. To evaluate the acute hepatotoxicity of equisentum arvense l. Ethanol treatment to albino rats for 8 weeks induced a fair degree of derangement of liver structure and function. Paracetamol induced hepatotoxicity12 rats were divided into following six groups of 6 each. Drug induced hepatotoxicity is the most common reason cited for withdrawal of already approved drugs from the market and accounts for more than 50 percent. Starvation significantly decreased the urinary excretion of both cs2 and its bivalent sulphur. Prior a sohelia korourian e emanuele albano f magnus ingelmansundberg c dennis r.
Rosmarinic acid attenuates the hepatotoxicity induced by. Hesperidin and curdlan treatment ameliorates i 3 radiation induced cellular damage and oxidative stress in the liver of spraguedawley rats. Pdf diet and risk of ethanolinduced hepatotoxicity. Mill roots against paracetamol induced hepatotoxicity in. Hepatoprotective effect of flaxseed and its protein on ethanol. Hepatotoxicity in rats treated with dimethylformamide or toluene. Effects of nacetylcysteine on ethanolinduced hepatotoxicity.
From the division of digestive and liver diseases, department of internal medicine, university of texas southwestern medical center, dallas. Severe hepatotoxicity and nephrotoxicity of gasoline petrol. Ameliorative effect of flaxseed linum usitatissimum and. Protective effect of genistein against nnitrosodiethylamine. Study of acute hepatotoxicity of equisetum arvense l. Preliminary toxicity study to determine the volume of gasoline that could cause toxicity was carried out using 56 healthy male albino rats. Histopathological evaluation of diethyl phthalate induced hepatotoxicity on rat. Sulforaphane potentially ameliorates arsenic induced. Sadenosylmethionine same protects against acute alcohol induced hepatotoxicity in mice small star, filled. The aim of the present study was to investigate the hepatoprotective activity of oleogumresin ogr in rats. Hepatotoxicity was induced in male wistar rat by pcm 2 gkg. Hepatoprotective potential of andrographis paniculata aqueous.
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